Genetically Engineering the Nervous System with CRISPR-Cas
نویسندگان
چکیده
منابع مشابه
The CRISPR/Cas System
The epigenome is a heritable layer of information not encoded in the DNA sequence of the genome, but in chemical modifications of DNA or histones. These chemical modifications, together with transcription factors, operate as spatiotemporal regulators of genome activity. Dissecting epigenome function requires controlled site-specific alteration of epigenetic information. Such control can be obta...
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Differences in genomes underlie most organismal diversity, and aberrations in genomes underlie many disease states. With the growing knowledge of the genetic and pathogenic basis of human disease, development of safe and efficient platforms for genome and epigenome engineering will transform our ability to therapeutically target human diseases and also potentially engineer disease resistance. I...
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ژورنال
عنوان ژورنال: eneuro
سال: 2020
ISSN: 2373-2822
DOI: 10.1523/eneuro.0419-19.2020